Category: Matter

Things that matter, such as professional work or published writing.

Objections to Prevention

Post author By Michael A. Castello
Post date July 20, 2020

"Rationing means a fair share for all of us." Fair? That sounds like socialism!

A rundown of objections to COVID-19 prevention strategies, and why those objections are wrong.Continue readingObjections to Prevention

Tags clinical.medicine, covid.19, health

Rule In, Rule Out

Post author By Michael A. Castello
Post date July 17, 2020

Setting the cutoff at A represents 100% sensitivity. All positives (pink curve) are true positives, but some negatives are false negatives (purple shading). Moving the cutoff to C represents 100% specificity. All negatives (blue curve) are true negatives, but some positives are false positives. Setting a cutoff in the middle at B is a compromise between the two.

Looking at false positives, false negatives, and what that means for COVID-19 testing.Continue readingRule In, Rule Out

Tags clinical.medicine, covid.19, research

A Headache of a Headache

Post author By Michael A. Castello
Post date April 29, 2020

Clinical case presentation given in partial fulfillment of the UCSD Child Neurology residency program. Among other things, working through this particular case emphasized the broad differential diagnosis of aseptic meningitis. Available on Google Slides or…Continue readingA Headache of a Headache

Tags clinical.medicine, neurology, residency

COVID-19

Post author By Michael A. Castello
Post date March 21, 2020
2 Comments on COVID-19
Sticky post

My collection of information, resources, and articles about COVID-19.Continue readingCOVID-19

Tags clinical.medicine, covid.19, health, reference.information

Lipid Regulation as a Critical Factor in the Development of Alzheimer’s Disease

Post author By Michael A. Castello
Post date September 6, 2014

PhD Thesis Defense presented by Michael A. Castello on Friday, September 5, 2014.Continue readingLipid Regulation as a Critical Factor in the Development of Alzheimer’s Disease

Tags grad.school, neuroscience, presentation, research

APP Regulates Brain Lipid Homeostasis

Post author By Michael A. Castello
Post date November 10, 2013

Presentation at Neuroscience 2013; November 10, 2013. Available on Prezi or for download.Continue readingAPP Regulates Brain Lipid Homeostasis

Tags alzheimers.disease, conferences, neuroscience, presentation, research

Unveiling Pathogenic Mechanisms in Niemann-Pick Type C Disease

Post author By Michael A. Castello
Post date June 14, 2013

Presentation for Parseghian Foundation Conference 2013. Available on Prezi or for download.Continue readingUnveiling Pathogenic Mechanisms in Niemann-Pick Type C Disease

Tags conferences, neuroscience, niemann.pick.type.c, presentation, research

Testing an Adaptive Response Hypothesis of Alzheimer’s Disease

Post author By Michael A. Castello
Post date February 11, 2013

Loma Linda University Monday Seminar presentation, February 11, 2013. Also available on Prezi or for download.Continue readingTesting an Adaptive Response Hypothesis of Alzheimer’s Disease

Tags alzheimers.disease, grad.school, neuroscience, presentation, research