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Matter Science

Lipid Regulation as a Critical Factor in the Development of Alzheimer’s Disease

PhD Thesis Defense presented by Michael A. Castello on Friday, September 5, 2014.Continue readingLipid Regulation as a Critical Factor in the Development of Alzheimer’s Disease

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Matter Science

APP Regulates Brain Lipid Homeostasis

Presentation at Neuroscience 2013; November 10, 2013. Available on Prezi or for download.Continue readingAPP Regulates Brain Lipid Homeostasis

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Matter Science

Unveiling Pathogenic Mechanisms in Niemann-Pick Type C Disease

Presentation for Parseghian Foundation Conference 2013. Available on Prezi or for download.Continue readingUnveiling Pathogenic Mechanisms in Niemann-Pick Type C Disease

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Matter Science

Testing an Adaptive Response Hypothesis of Alzheimer’s Disease

Loma Linda University Monday Seminar presentation, February 11, 2013. Also available on Prezi or for download.Continue readingTesting an Adaptive Response Hypothesis of Alzheimer’s Disease

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Short Reads

PhD Candidate!

Yesterday I presented and defended my PhD thesis. Spoiler: I passed! I’m now a PhD candidate, meaning that the only thing standing between me and my first doctorate…is more than a year of dedicated research.…Continue readingPhD Candidate!

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Matter Science

Cholesterol Dysregulation and Neurodegenerative Disease

Thesis proposal by Michael A. Castello, presented on October 26, 2012.Continue readingCholesterol Dysregulation and Neurodegenerative Disease

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Long Reads

Snapshot of a Researcher: Dr. Soriano

At least one person has told me her view of scientists was that they were all crazy white-haired men with accents. It got me thinking—I think that picture is close to a majority opinion. Indeed, if…Continue readingSnapshot of a Researcher: Dr. Soriano

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Long Reads

Science at 100x

Because you were so consumed with longing to know what I do in lab all day, here’s a picture of some immunofluorescence staining I’ve been working on. Blue is cholesterol (labeled with filipin), which has…Continue readingScience at 100x